Product Name：4, 6-dichlorouracil
4, 6-dichloropyrimidine, with low boiling point, is the starting material for the synthesis of disubstituted pyrimidine by tandem amination and Suzuki-Miyaura cross coupling reaction, as well as the production of sulfonamides.
Molecular formula: C4H2Cl2N2
Molecular weight: 170.1261
Melting point: 66 ~ 70 ℃
Boiling point: 176 ℃
CAS no. : 1193-21-1
Purity: 99% or higher
Flash point: 176 ℃
Solubility: insoluble in water, soluble in toluene and other organic solvents.
Appearance: pale yellow to white crystal
Content: 99.0% or higher
Packing: 25 kg/drum
Physical and chemical properties
Burning residue: ≤0.5% burning residue: ≤0.5%; Moisture 0.5% or less
Used as a pharmaceutical intermediate for the production of sulfa-6 - methoxil. Intermediate used in the synthesis of bactericide eschericin.
The starting materials of disubstituted pyrimidines were synthesized by tandem amination and Suzuki-Miyaura cross coupling reaction. It is also used in the synthesis of diaryl pyrimidines involved in cross coupling reactions of diaryl groups. The synthesis of pharmaceutical intermediates is mainly used in the production of sulfonamides.
Toxicity and protection
It can be decomposed into phosphorus oxychloride, phosphoric acid and hydrochloric acid by water in eyes and respiratory tract. Phosphorus pentachloride steam and smoke to the respiratory tract, eyes, oral mucosa has a very strong stimulation, follow-up sessions can cause burning pain, or difficulty swallowing, severe cases can be caused by laryngeal edema, suffocation, and may cause bronchitis, chemical pneumonia, pulmonary edema, chest can smell of dry and wet rale, this effect is similar to phosgene (COCI2), toxicity than phosphorus trichloride. Respiratory protection: when the concentration of air exceeds the limit, one must wear gas mask or air supply helmet. When emergency rescue or escape, it is recommended to wear self-contained breathing apparatus.
Packaging storage and transportation
Keep the storage container sealed and stored in a cool, dry place. Ensure the workshop has good ventilation or exhaust device.
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