Product Name：3 - chloro propyne
Chemical formula: C3H3CL
Molecular weight: 74.51
CAS no. : 624-65-7
Boiling point: 58 ℃
Physical and chemical properties
Colorless flammable liquid. Melting point -78c, boiling point 57C (65C), relative density 1.0297, refractive index 1.4320, flash point 32.2-35c, almost insoluble in water, glycerin, and benzene, carbon tetrachloride, ethanol, ethylene glycol, ether, ethyl acetate miscible.
1, as an organic synthesis intermediate. Used for making medicine youjiangning, soil fumigant and so on. It is also the modifier of engineering plastics, its trisodium salt is an excellent heat stabilizer of PVC, and its ester is an important additive of high polymer.
2, organic synthesis intermediates, such as used for making medicine, can also be used to make soil fumigant.
3, propargyl oxygen is a tri-carbon alkylation reagent, as well as the equivalent body of acetone carbene ion, ring adding reagent, when converted to metal organic reagent is propargyl or propylene nucleophile. As an electrophilic reagents, propargyl can be used to realize many substrates such as grignard reagent, carbon anion, enol, jun base compound, alcohol, phenol, ling acid ester, amine, amide, sulfanilamide, sulfone, mercaptan, sulfur acid and alkyl phosphate mouth fast base reaction , because this kind of reaction is conducted under alkaline conditions, thus inevitably occur isomerization reaction of propargyl chloride, chlorinated compounds allene, isomerization reaction depends on the degree of reaction time, temperature, and using alkali type. Propargyl halide can also be used for cyclic reaction. For example, mercury oxide can be added after alkylation reaction between propargyl bromide and substrate to obtain alkylation products similar to acetone. As alkylation reaction occurs in the carbonyl ortho, can enter - : step happens intramolecular cyclization reaction by cyclopentene ketone compounds (type 1). As a result of the alkylation reaction generated after compounds containing alkynyl, so also can further intramolecular rearrangement reaction, such as the generated alkynyl vinyl legs happen [1, 5) - oxygen migration, rearrangement of benzene and cefuroxime feed for closed-loop response (type 2). Propargyl chloride can react with furan, styrene and triaminobenzene intramolecular Diels Alder as a diolephile group . Propargyl oxide can also participate in the cycloaddition reaction of [3+2] as a 1, 3-dipole. As a halide, propargyl can also be converted into various organometallic reagents, which in the presence of diethyl tartrate react chiral with aldehydes or friends (equation 3)5].
Toxicity and protection
S16: stay away from fire. S26: in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27: remove all contaminated clothing immediately. S45: if you have an accident or feel unwell, seek help from your doctor immediately (preferably with product container labels). S36137139 wear suitable protective clothing, gloves and use protective glasses or mask.
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